TAILIEUCHUNG - Báo cáo khoa hoc:"Regression markers with uncertain allele transmission for QTL mapping in half-sib designs"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Regression markers with uncertain allele transmission for QTL mapping in half-sib designs | 437 Genet. Sei. Evol. 31 1999 437-455 Inra Elsevier Paris Original article Regression on markers with uncertain allele transmission for QTL mapping in half-sib designs Haja N. Kadarmideena Jack . Dekkers6 a Department of Animal and Poultry Science University of Guelph Guelph ON NIG 2W1 Canada b Department of Animal Science Iowa State University Ames IA 50011-3150 USA Received 22 September 1998 accepted 16 August 1999 Abstract - Recently regression of phenotype on marker genotypes was described for quantitative trait loci QTL mapping in F2 populations and shown to be equivalent to regression interval mapping RIM . In this study regression on markers was extended to half-sib designs with uncertain marker allele transmission and properties of QTL parameters were examined analytically. In this method offspring phenotypes are first regressed on the probability of transmission of a given allele from the common parent at flanking marker loci. Resulting regression coefficients can then be interpreted based on an assumed genetic model. With presence of a single QTL in the marker interval it was shown that expected values of regression coefficients for the flanking markers contained all information about position and effect of the QTL and were independent of the probability of marker allele transmission. Through simulation it was shown that regression of phenotype on marker allele transmission probabilities is equivalent to RIM under the same assumed genetic model. Regression on marker genotypes is computationally less time consuming than QTL interval mapping as it eliminates the need to search for the best QTL position across marker intervals. This can form the basis for more efficient methods of analysis with more complex models including threshold or logistic models for the analysis of categorical traits. Inra Elsevier Paris genetic marker QTL mapping half-sib design Resume Detection de QTLs dans des families de demi-freres par regression sur des marqueurs avec .

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