TAILIEUCHUNG - CANCER CHEMOPREVENTION WITH DIETARY PHYTOCHEMICALS

Support groups led by our social workers are a good place to exchange information and share experiences with other people in similar situations, which can make it easier to cope. Our social workers also help you find the practical help you might need, such as financial assistance or tips on managing side effects. All of CancerCare’s services, offered by telephone, online, and face to face, are completely free of charge. By talking with your children honestly and helping them express their emotions, you make it easier for them to feel safe and secure. And as their parent, you are the. | REVI EWS CANCER CHEMOPREVENTION WITH DIETARY PHYTOCHEMICALS Young-Joon Surh Chemoprevention refers to the use of agents to inhibit reverse or retard tumorigenesis. Numerous phytochemicals derived from edible plants have been reported to interfere with a specific stage of the carcinogenic process. Many mechanisms have been shown to account for the anticarcinogenic actions of dietary constituents but attention has recently been focused on intracellular-signalling cascades as common molecular targets for various chemopreventive phytochemicals. College of Pharmacy Seoul National University Shinlim-dong Kwanak-ku Seoul 151-742 South Korea. e-mail surh@ doi nrc1189 Cancer is a growing health problem around the world particularly with the steady rise in life expectancy increasing urbanization and the subsequent changes in environmental conditions including lifestyle. According to a recent report by the World Health Organization WHO there are now more than 10 million cases of cancer per year worldwide. In 2003 it is estimated that approximately 1 300 000 new cases of cancer will be diagnosed and more than 550 000 people will die from cancer in the United States alone. Although there is no magic bullet that can completely conquer cancer many types of the disease might be avoidable. Cancer risk can be reduced by eliminating the identified carcinogens or at least minimizing exposure to them but without complete identification of the corresponding risk factors such primary prevention might be difficult to implement. Furthermore the avoidance of some risk factors could require large lifestyle changes which are not easy to implement. It has been estimated that more than two-thirds of human cancers could be prevented through appropriate lifestyle modification. Richard Doll and Richard Peto have reported that 10-70 average 35 of human cancer mortality is attributable to diet1. Their observations which are based on statistical and epidemiological data mainly

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