TAILIEUCHUNG - Báo cáo khoa hoc:" Sire design power calculation for QTL mapping experiments"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Sire design power calculation for QTL mapping experiments | 183 Genet. Sei. Evol. 31 1999 183-189 Inra Elsevier Paris Note Sire design power calculation for QTL mapping experiments Antonello Cartaa Jean-Michel Elsenb a Istituto Zootecnico e Caseario per la Sardegna Bonassai 07040 Olmedo SS Italy b Station d amelioration génétique des animaux Inra BP 27 31326 Castanet-Tolosan cedex France Received 25 May 1998 accepted 2 February 1999 Abstract - Estimates of sire design power for QTL mapping experiments obtained using three different methods of algebraic approximation were analysed by comparing them with the results of data simulations. Even when the binomial probability that any number of sires out of the total number of sires are jointly heterozygous at the marker and the QT loci was taken into consideration the algebraic approximations overestimated powers. However they could be used to rank designs differing in the number of sires if the total size of the experiment is given. The results were discussed focusing on the assumptions made about the number of informative offspring the balance between the two offspring sub-groups which receive the same marker allele from the sire and the distribution of the statistic. Given that a full algebraic approach would be computationally costly data simulation can be considered a useful tool in estimating the power of QTL detection sire designs. Inra Elsevier Paris QTL power simulation protocol design Resume - Calcul de la puissance de detection de QTL dans un modèle père . Trois methodes analytiques pour 1 estimation de la puissance du protocole fille pour la detection des QTLs à 1 aide d un marqueur flanquant ont été étudiées en comparaison avec des résultats obtenus par simulation. Ces estimations sont surestimées même quand est prise en compte la distribution de probabilité du nombre de pères double heterozygotes au marqueur et au QTL. Cependant elles peuvent être utilisées pour classer des protocoles de faẹon relative à taille de population totale fixee. Les résultats sont discutés

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