TAILIEUCHUNG - Báo cáo khoa học: "Neuropharmacological effects of deltamethrin in rats"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Neuropharmacological effects of deltamethrin in rats | J. Vet. Set. 2006 7 2 137-141 JOURNAL OF Veterinary Science Experimental peritonitis induced by oral administration of indomethacin in Mongolian gerbils Okjin Kim Jin-Uk Lee3 1 Animal Disease Research Unit Center for Animal Resources Development 2Institute of Life Science and Natural Resources College of Life Science and Natural Resources Wonkwang University Iksan 570-749 Korea 3Department of Laboratory Animal Sciences College of Medicine Seoul National University Seoul 110-719 Korea The possibility of inducing peritoneal inflammation in three murine species gerbils rats and mice via the oral administration of indomethacin was investigated with the overall aim of developing an experimental animal model for human peritonitis. Gerbils given high doses of indomethacin at a rate of 30 mg and 40 mg kg body weight showed swelling of the abdomen depression and dyspnea within 4 days after the treatment. The severity of the clinical symptoms increased with time. The animals were confirmed as having developed peritonitis based on the pathological features including inflammation of the peritoneum and fibrinous adhesion of the abdominal organs in the abdominal cavity. The severity of peritonitis increased with increasing dose of indomethacin and was not related to the gender of the animal. On the other hand peritoneal inflammation did not develop in the rats and mice even at high doses. Therefore the administration of 30 mg kg body weight of indomethacin is an effective and simple method of inducing peritonitis in 5-week-old Mongolian gerbils. The animal peritonitis model used in this study can be used as an effective tool for examining potential therapeutic compounds for preventing peritoneal damage during peritonitis and provide insight into the pathophysiology of peritonitis. Key words animal model indomethacin Mongolian gerbil peritonitis Introduction Peritonitis is inflammation of the peritoneum. It is different from the inflammatory changes brought about by this .

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