TAILIEUCHUNG - Báo cáo khoa học: " Effect of probiotic containing Saccharomyces boulardii on experimental ochratoxicosis in broilers: hematobiochemical studies"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Effect of soluble porcine aminopeptidase N on antibody production against porcine epidemic diarrhea virus | J. Vet. Sci. 2004 5 4 353-357 JOURNAL OF Veterinary Science Effect of soluble porcine aminopeptidase N on antibody production against porcine epidemic diarrhea virus Jin Sik Oh1 Dae Sub Song1 Jeong Sun Yang1 Ju Young Song1 Han Sang Yoo2 Yong Suk Jang3 Bong Kyun Park1 1 Department of Veterinary Virology College of Veterinary Medicine and School of Agricultural Biotechnology Seoul National University Seoul 151-742 Korea 2Department of Veterinary Infectious Disease College of Veterinary Medicine and School of Agricultural Biotechnology Seoul National University Seoul 151-742 Korea 3 Division of Biological Science and the Institute for Molecular Biology and Genetics Chonbuk National University Jeonju 561-756 Korea A few members of coronavirus group I which includes porcine epidemic diarrhea virus PEDV use porcine aminopeptidase N pAPN as a cellular receptor. Cellular receptors play an important role in virus attachment and entry. However the low permissiveness of PEDV to APN-expressing porcine cell lines has made it difficult to elucidate the role of pAPN in vitro. The purpose of this study was to prove whether the treatment of soluble pAPN could enhance the antibody production against PEDV in guinea pigs rabbits and sows. The animals 20 guinea pigs 8 rabbits and 20 sows were divided into 4 groups. Group A was injected intramuscularly IM with soluble pAPN at one hour before intramuscular infection of PEDV on the same site group B for IM simultaneous injection of pAPN and PEDV and group C for IM injection of PEDV only. Group D served as a control of pAPN treatment or PEDV infection. Antibody production against PEDV was compared among groups at regular intervals. The results suggested that pAPN could enhance the antibody production against PEDV in guinea pigs and rabbits which are free of pAPN however the effect of pAPN treatment in sows was not clearly elucidated. Key words Porcine epidemic diarrhea virus porcine aminopeptidase N immune responses Introduction .

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