TAILIEUCHUNG - Báo cáo khoa học: "Frequencies of Micronuclei in Peripheral Lymphocytes in Korean Populations after Chronic Low-dose Radiation Exposure"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Frequencies of Micronuclei in Peripheral Lymphocytes in Korean Populations after Chronic Low-dose Radiation Exposure | J. Vet. Sci. 2002 3 3 213-218 JOURNAL OF Veterinary Science Frequencies of Micronuclei in Peripheral Lymphocytes in Korean Populations after Chronic Low-dose Radiation Exposure Mi-Young An1 and Tae-Hwan Kim lLaboratory of Radiation Effect Korea Cancer Center Hospital Department of Small Animal Medicine and Surgery College of Veterinary Medicine 4474 Texas A M University College Station Tx. 77843-4474 . Received July 22 2002 Accepted September 3 2002 Abstract The purpose of this study was to estimate predictive markers of intrinsic radiosensitivity in individuals who were exposed to occupational or environmental radiation. Throughout this process the actual biohazard risks and base-line chromosome damage were evaluated in human population. Further studies were carried out to provide evidence for the existence of individual variations in age-dependent responses through micronuclei MN assay. Spontaneous frequencies not only vary greatly between individuals but also working or living areas. It was shown that the increased level of spontaneous cell with MN was observed with increasing age. The relationship between radiosensitivity and the increased spontaneous level of MN may be in an inverse proportion. Ionizing radiation may be targeted mutagenic effects at the usual exposures of background levels that populations were exposed. Age and gender are the most important demographic variables in determining the MN index with frequencies in females which were greater than those in males. The main life-style factors influencing the MN index in subjects were correlated significantly and positively with smoke. The results showed that an indicator of the genetic damaged rate in MN index in human populations significantly correlated with age sex and life-style factors. So far it is evident that with regard to the application of MN assay all future studies have to take into account the influence of age gender and life-style. In Conclusion using micronuclei assay technique a .

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