TAILIEUCHUNG - Chapter 3: Cellular Structure and Function

Understanding the concepts presented in this chapter will enable the student to: 1. Describe the function of the following cellular components of cardiac myocytes: sarcolemma, intercalated disks, transverse (T)-tubules, myofibrils, myofilaments, sarcomeres, sarcoplasmic reticulum, and terminal cisternae. 2. Describe the composition of thick and thin myofilaments in cardiac myocytes. 3. Describe the significance of a functional syncytium within the heart. 4. Describe the steps of excitation–contraction coupling, including the role of T tubules, Ltype calcium channels, trigger calcium, terminal cisternae, ryanodine receptors (calciumrelease channels), troponin-C (TN-C), troponin-I (TN-I), troponin-T (TN-T), actin, myosin heads, adenosine triphosphate (ATP) hydrolysis, and sarco-endoplasmic reticulum calcium adenosine triphosphatase (SERCA) pump | cha pter Cellular Structure and Function 3 CD-ROM CONTENTS LEARNING OBJECTIVES INTRODUCTION CARDIAC CELL STRUCTURE AND FUNCTION Myocytes and Sarcomeres Excitation-Contraction Coupling Regulation of Contraction Inotropy Regulation of Relaxation Lusitropy Cardiac Myocyte Metabolism VASCULAR STRUCTURE AND FUNCTION Vascular Smooth Muscle Cells Vascular Endothelial Cells SUMMARY OF IMPORTANT CONCEPTS REVIEW QUESTIONS SUGGESTED READINGS CD CONTENTS 1. Formation and Physiologic Actions of Nitric Oxide 2. Formation and Physiologic Actions of Endothelin-1 3. Formation and Physiologic Actions of Metabolites of Arachidonic Acid LEARNING OBJECTIVES Understanding the concepts presented in this chapter will enable the student to 1. Describe the function of the following cellular components of cardiac myocytes sar-colemma intercalated disks transverse T -tubules myofibrils myofilaments sarcomeres sarcoplasmic reticulum and terminal cisternae. 2. Describe the composition of thick and thin myofilaments in cardiac myocytes. 3. Describe the significance of a functional syncytium within the heart. 4. Describe the steps of excitation-contraction coupling including the role of T tubules L-type calcium channels trigger calcium terminal cisternae ryanodine receptors calcium-release channels troponin-C TN-C troponin-I TN-I troponin-T TN-T actin myosin heads adenosine triphosphate ATP hydrolysis and sarco-endoplasmic reticulum calcium adenosine triphosphatase SERCA pump. 5. List several mechanisms involved in the regulation of cardiac inotropy and lusitropy. 6. List in order of preference the metabolic substrates used by the heart and summarize the importance of oxidative metabolism relative to anaerobic metabolism. 7. Draw the cross section of a muscular artery label the three layers and list the major components of each layer. 8. Contrast the organization of actin and myosin in vascular smooth muscle with the organization of these myofilaments in cardiac myocytes. 9. Describe the .

• Y học thường thức
• medical books
• pharmacology
• epidemiologic
• Obstetrics
• anatomy
• Preventing Morbidity
• Multidisciplinary Care
• Biomedical Electronics
• Medical Equipment
• Medical Imaging
• Electronic Medical Records
• Image Data Compression
• radiation physics
• Modern Physics
• medical physiscists
• Interaction Mechanisms
• Medical Applications
• Laser Safety
• Biological Considerations
• Intraocular
• Retinal Prosthesis
• Probability Theory
• Random Processes
• Engineering Statistics
• Microfluidic Devices
• Microfabricated Devices
• Cell Manipulation
• Bioinstrumentation
• Circuit Theory
• Introductory Biomedical Engineering
• Sacrificial Oxide Layer
• Drug Delivery
• Nanofabrication
• developmental systems
• Cleavage
• lumen formation
• blastula formation
• Electricity Inside Us
• Heart Pulse
• Crocodile Tears
• Mechanics
• Molecular Transport
• Regulation
• Microcirculation
• Gene Expression
• Extracellular Matrix
• physiology
• Capstone Design Experience
• Meet Student Needs
• Changing Needs
• Integrated Wholes
• General System Theory
• Systems Biology
• Empirical Force Fields
• Computational Methods
• Domain Partitioning
• Basic Principles
• Tissue Engineering
• Cell Culture
• biological basis
• The cytoskeleton
• cell mechanics
• Larger Organisms
• Cell Populations
• Individual Cells
• Emergent Computation
• Automata Theory
• Bioinformatics
• Biomedical research
• Clinical research
• Human stem cells
• Functional Genomics
• Interpreting Microarray
• Proteomics