TAILIEUCHUNG - Báo cáo vật lý: "Resveratrol Derivatives from Stem Bark of Hopea and Their Biological Activity Test"

Tuyển tập các báo cáo nghiên cứu khoa học trên tạp chí khoa học vật lý quốc tế đề tài: Resveratrol Derivatives from Stem Bark of Hopea and Their Biological Activity Test | Journal of Physical Science Vol. 19 2 7-21 2008 7 Resveratrol Derivatives from Stem Bark of Hopea and Their Biological Activity Test Sri Atun1 Nurfina Aznam1 Retno Arianingrum1 Y. Takaya 2 and Niwa Masatake2 department Chemistry Education Universitas Negeri Yogyakarta Karangmalang Depok Sleman Yogyakarta 55281 Indonesia 2Faculty of Pharmacy Meijo University Tempaku Nagoya Japan Corresponding author Atun_1210@ Abstract From the stem bark of Hopea odorata H. mengarawan and H. nigra seven known resveratrol derivatives named balanocarpol 1 heimiol A 2 vaticanol G 3 vaticanol B 4 hopeaphenol 5 ampelopsin H 6 and hemlesyanol C 7 were isolated. The structure was elucidated by NMR spectroscopy including 1D and 2D NMR. Some compounds showed antioxidant activity and cytotoxicity againt HeLa-S3 and Raji cell. Keywords resveratrol derivatives Hopea odorata H. mengarawan H. nigra antioxidant cytotoxicity 1. INTRODUCTION Hopea is one of the main genus of Dipterocarpaceae consisting of approximately 100 species and widely distributed in Indonesia specially in Kalimantan1 2 and until now only few species have been investigated. This family of plant is known to produce a variety of resveratrol These structures are very interesting and showed interesting biological activity such as antibacterial anticancer antihepatotoxic and Thus Dipterocarpaceae plants are very promising for chemical research in natural product and pharmaceutical industry. In our continuing phytochemical study of the Dipterocarpaceae family occuring in Indonesia we have examined resveratrol oligomer constituents from some species of Hopea odorata H. mengarawan and H. nigra. Hopea is widely distributed in tropical rain forest of Sumatra Malaysia and up to the Andaman islands and it is locally known as merawan hitam or pengarawan3 This paper reports first investigation of seven resveratrol derivatives from the stem bark of these species. The structures of these compounds were .

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