TAILIEUCHUNG - Báo cáo khoa học: TRB3, upregulated by ox-LDL, mediates human monocyte-derived macrophage apoptosis

Tribble3 (TRB3), a mammalian homolog ofDrosophilatribbles, slows cell-cycle progression, and its expression is increased in response to various stresses. The aim of this study was to investigate the role of theTRB3gene in macrophage apoptosis induced by oxidized low-density lipoprotein (ox-LDL). We found that, in human monocyte-derived macrophages, TRB3is upregulated by ox-LDL in a dose- and time-dependent manner. | TRB3 upregulated by ox-LDL mediates human monocyte-derived macrophage apoptosis Yuan-yuan Shang1 Zhi-hao Wang1 Li-ping Zhang2 Ming Zhong1 Yun Zhang1 Jing-ti Deng2 and Wei Zhang1 1 Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Public Health Department of Cardiology Qilu Hospitalof Shandong University Ji nan China 2 Department of Anatomy Schoolof Medicine Shandong University Ji nan China Keywords apoptosis atherosclerosis macrophage ox-LDL TRB3 Correspondence W. Zhang Department of Cardiology Qilu Hospitalof Shandong University Ji nan 250012 China Fax 86 531 86169356 Tel 86 531 82169339 E-mail zhangweisdu@ . Deng Department of Anatomy School of Medicine of Shandong University Ji nan 250012 China Fax 86 531 86169356 Tel 86 531 88382093 E-mail jingtideng@ These authors contributed equally to this paper Received 16 January 2009 revised 4 March 2009 accepted 9 March 2009 doi Tribble3 TRB3 a mammalian homolog of Drosophila tribbles slows cellcycle progression and its expression is increased in response to various stresses. The aim of this study was to investigate the role of the TRB3 gene in macrophage apoptosis induced by oxidized low-density lipoprotein ox-LDL . We found that in human monocyte-derived macrophages TRB3 is upregulated by ox-LDL in a dose- and time-dependent manner. The cell viability of TRB3-overexpressing macrophages was decreased but apoptosis was increased and the level of activated caspase-3 increased. Factorial analyses revealed no significant interaction between TRB3 overexpression and ox-LDL stimulation with respect to macrophage apoptosis. Furthermore TRB3-silenced macrophages showed decreased apoptosis and TRB3-silenced cells treated with ox-LDL showed significantly increased apoptosis. Silencing of TRB3 and ox-LDL stimulation showed significant interaction for macrophage apoptosis suggesting that TRB3 knockdown .

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