TAILIEUCHUNG - Báo cáo sinh học: "Cancer stem cell subsets and their relationship"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Cancer stem cell subsets and their relationship | Liu et al. Journal of Translational Medicine 2011 9 50 http content 9 1 50 JOURNAL OF TRANSLATIONAL MEDICINE REVIEW Open Access Cancer stem cell subsets and their relationships Hai-Guang Liu Chong Chen Han Yang Yi-Fei Pan and Xiao-Hua Zhang Abstract Emerging evidence suggests that cancer stem cells account for the initiation and progression of cancer. While many types of cancer stem cells with specific markers have been isolated and identified a variety of differences among them began to be appreciated. Cancer stem cells are hierarchical populations that consist of precancerous stem cells primary cancer stem cells migrating cancer stem cells and chemoradioresistant cancer stem cells playing different roles in cancer initiation and progression. Here we propose a new concept horizontal hierarchy of cancer stem cells to distinguish them from vertical hierarchy cancer stem cells cancer transient-amplifying cells and cancer differentiated cells and summarize our current understanding of these subsets of cancer stem cells with the aim to open up novel therapeutic strategies for cancer based on this understanding. Introduction Cancer is a kind of abnormal tissue that develops the ability of unlimited growth and the resistance to various survival stresses. Recently accumulating experimental evidence supports that cancer stem cells account for the initiation and progression of cancer which challenges the classical stochastic model of cancer development 1 . The cancer stem cell model or intrinsic model posits similar differentiation hierarchy such as hematopoietic system cancer stem cells cancer transient-amplifying TA cells and cancer differentiated cells which is defined as vertical hierarchy here. Only cancer stem cells or cancer TA cells that reacquire self-renewal property can initiate cancer and progress into more malignant disease. However in the stochastic model no hierarchy in cancer exists and every single cancer cell has the capacity

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