TAILIEUCHUNG - báo cáo hóa học: " Exploring the validity of estimating EQ-5D and SF-6D utility values from the health assessment questionnaire in patients with inflammatory arthritis"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí hóa học quốc tế đề tài : Exploring the validity of estimating EQ-5D and SF-6D utility values from the health assessment questionnaire in patients with inflammatory arthritis | Harrison et al. Health and Quality of Life Outcomes 2010 8 21 http content 8 1 21 HEALTH AND QUALITY of life outcomes RESEARCH Open Access Exploring the validity of estimating EQ-5D and SF-6D utility values from the health assessment questionnaire in patients with inflammatory arthritis 11 112 Mark J Harrison Mark Lunt Suzanne MM Verstappen Kath D Watson Nick J Bansback Deborah PM Symmons1 Abstract Background Utility scores are used to estimate Quality Adjusted Life Years QALYs applied in determining the cost-effectiveness of health care interventions. In studies where no preference based measures are collected indirect methods have been developed to estimate utilities from clinical instruments. The aim of this study was to evaluate a published method of estimating the EuroQol-5D EQ-5D and Short Form-6D SF-6D preference based utility scores from the Health Assessment Questionnaire HAQ in patients with inflammatory arthritis. Methods Data were used from 3 cohorts of patients with early inflammatory arthritis 10 weeks duration established 5 years duration stable rheumatoid arthritis RA and RA being treated with anti-TNF therapy. Patients completed the EQ-5D SF-6D and HAQ at baseline and a follow-up assessment. EQ-5D and SF-6D scores were predicted from the HAQ using a published method. Differences between predicted and observed EQ-5D and SF-6D scores were assessed using the paired t-test and linear regression. Results Predicted utility scores were generally higher than observed scores range of differences EQ-5D SF-6D - . Change between predicted values of the EQ-5D and SF-6D corresponded well with observed change in patients with established RA. Change in predicted SF-6D scores was however less than half of that in observed values p in patients with more active disease. Predicted EQ-5D scores underestimated change in cohorts of patients with more active disease. Conclusion Predicted utility scores overestimated baseline values

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