TAILIEUCHUNG - Báo cáo y học: "Mathematical models in mammalian cell biology"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Mathematical models in mammalian cell biology. | Meeting report Mathematical models in mammalian cell biology Hanspeter Herzel and Nils Bluthgen Addresses Institute for Theoretical Biology Humboldt University Invalidenstrasse 10115 Berlin Germany. institute of Pathology Charité Schumannstr. D-10117 Berlin Germany. Correspondence Hanspeter Herzel. Email Published 15 July 2008 Genome Biology 2008 9 316 doi gb-2008-9-7-316 The electronic version of this article is the complete one and can be found online at http 2008 9 7 316 2008 BioMed Central Ltd A report on the Conference on Systems Biology of Mammalian Cells Dresden Germany 22-24 May 2008. Systems biology has been defined in many ways emphasizing various aspects of interdisciplinary research. At the recent symposium in Dresden on systems biology of mammalian cells this emerging field was presented as a fruitful symbiosis of genomics imaging and high- and mediumthroughput technologies with data analysis and mathematical modeling. Here we focus on selected applications of mathematical modeling in mammalian cell biology - a challenging but promising branch of systems biology. Mathematically modeling the circadian clock One application of mathematical models is in analyzing the workings of the mammalian circadian clock. About 20 000 synchronized neurons in the suprachiasmatic nucleus SCN control daily rhythms of physiology metabolism and behavior. In addition almost all peripheral tissues of mammals and even cell lines contain cellular clocks in which endogenous oscillations of mRNA and protein abundance rhythms with a period of about 24 hours are driven by intracellular feedback loops involving clock genes such as Perl-2 Cryi-2 Clock and Bmali. Post-translational events such as phosphorylation of clock proteins contribute to the delay in negative feedback and thus are crucial for the dynamics of circadian rhythms. One of us HH reported that a combination of experiments in the lab of Achim Kramer and .

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