TAILIEUCHUNG - Báo cáo y học: "The Hedgehog protein family"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: The Hedgehog protein family. | Protein family review The Hedgehog protein family Thomas R Burglin Address Department of Biosciences and Nutrition Karolinska Institutet and School of Life Sciences Sodertorn University Halsovagen 7 SE-141 57 Huddinge Sweden. Email Published 19 November 2008 Genome Biology 2008 9 241 doi gb-2008-9-11-241 The electronic version of this article is the complete one and can be found online at http 2008 9 11 241 2008 BioMed Central Ltd Summary The Hedgehog Hh pathway is one of the fundamental signal transduction pathways in animal development and is also involved in stem-cell maintenance and carcinogenesis. The hedgehog hh gene was first discovered in Drosophila and members of the family have since been found in most metazoa. Hh proteins are composed of two domains an amino-terminal domain HhN which has the biological signal activity and a carboxy-terminal autocatalytic domain HhC which cleaves Hh into two parts in an intramolecular reaction and adds a cholesterol moiety to HhN. HhC has sequence similarity to the self-splicing inteins and the shared region is termed Hint. New classes of proteins containing the Hint domain have been discovered recently in bacteria and eukaryotes and the Hog class of which Hh proteins comprise one family is widespread throughout eukaryotes. The non-Hh Hog proteins have carboxy-terminal domains the Hog domain highly similar to HhC although they lack the HhN domain and instead have other amino-terminal domains. Hog proteins are found in many protists but the Hh family emerged only in early metazoan evolution. HhN is modified by cholesterol at its carboxyl terminus and by palmitate at its amino terminus in both flies and mammals. The modified HhN is released from the cell and travels through the extracellular space. On binding its receptor Patched it relieves the inhibition that Patched exerts on Smoothened a G-protein-coupled receptor. The resulting signaling cascade converges on the .

TỪ KHÓA LIÊN QUAN
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.