TAILIEUCHUNG - Báo cáo y học: "Chlamydia trachomatis diversity viewed as a tissue-specific coevolutionary arms race"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Chlamydia trachomatis diversity viewed as a tissue-specific coevolutionary arms race. | Open Access Research Chlamydia trachomatis diversity viewed as a tissue-specific coevolutionary arms race Alexandra Nunes Paulo J Nogueira Maria J Borrego and João P Gomes Addresses Department of Infectious Diseases National Institute of Health Av. Padre Cruz 1649-016 Lisbon Portugal. Department of Epidemiology National Institute of Health Av. Padre Cruz 1649-016 Lisbon Portugal. Correspondence João P Gomes. Email Published 23 October 2008 Genome Biology 2008 9 R153 doi gb-2008-9- 10-r 153 The electronic version of this article is the complete one and can be found online at http 2008 9 10 R153 Received 28 July 2008 Revised 26 September 2008 Accepted 23 October 2008 2008 Nunes et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The genomes of pathogens are thought to have evolved under selective pressure provided by the host in a coevolutionary arms race the Red Queen s Hypothesis . Traditionally adaptation by pathogens is thought to rely not on whole chromosome dynamics but on gain loss of specific genes yielding differential abilities to infect distinct tissues. Thus it is not known whether distinct host organs differently shape the genome of the same pathogen. We tested this hypothesis using Chlamydia trachomatis as model species looking at 15 serovars that infect different organs eyes genitalia and lymph nodes. Results We analyzed over 51 000 base pairs from all serovars using various phylogenetic approaches and a non-phylogenetic indel-based algorithm to study the evolution of individual and concatenated loci. This survey comprised about 33 of all single nucleotide polymorphisms in C. trachomatis chromosomes. We present a model in which .

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