TAILIEUCHUNG - Báo cáo y học: "Bacterial pathogens encode suppressors of RNA-mediated silencing"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Bacterial pathogens encode suppressors of RNA-mediated silencing. | Minireview Bacterial pathogens encode suppressors of RNA-mediated silencing Rebecca A Mosher and David C Baulcombe Address Plant Sciences Department Cambridge University Downing Street Cambridge CB2 3EA UK. Correspondence David C Baulcombe. Email dcb40@ Published 17 October 2008 Genome Biology 2008 9 237 doi gb-2008-9-10-237 The electronic version of this article is the complete one and can be found online at http 2008 9 10 237 2008 BioMed Central Ltd Abstract Plant pathogenic bacteria encounter host defenses mediated by a variety of small RNAs. Bacterial suppressors of silencing that inhibit multiple steps of plant microRNA biogenesis and function have recently been identified. Resistance of plants to the pathogenic bacteria that infect them involves elaborate defense and counter-defense systems. The initial plant defense reaction known as PAMP-triggered immunity PTI follows from the recognition of one of many pathogen-associated molecular patterns PAMPs such as components of the bacterial flagellum or the bacterial translational machinery Figure 1 1 . To counteract PTI bacteria inject dozens of effector proteins into the plant cell via a specialized secretion system. These effector proteins alter the plant cell s transcriptome and proteome to reprogram the cell to become susceptible to the pathogen. If the effector molecules are recognized by the host cell they trigger an additional layer of defense known as effector-triggered immunity ETI see Figure 1 1 . In the past few years silencing of plant gene expression via host-encoded small RNAs has been implicated in both PTI and ETI 2 3 . Work from the laboratory of Olivier Voinnet published recently in Science Navarro et al. 4 sheds further light on this struggle between pathogen and host by identifying a mechanism by which the bacterial pathogen can suppress the RNA-mediated silencing of endogenous gene expression that helps set up the state of PTI. The first evidence that small .

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