TAILIEUCHUNG - Báo cáo y học: "Condensin goes with the family but not with the flow"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Condensin goes with the family but not with the flow. | Minireview Condensin goes with the family but not with the flow Marc R Gartenberg and Matthias Merkenschlager Addresses Department of Pharmacology Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey Piscataway NJ 08854 USA. lymphocyte Development Group MRC Clinical Sciences Centre Imperial College London W12 0NN UK. Correspondence Marc R Gartenberg. Email gartenbe@. Matthias Merkenschlager. Email . Published 6 October 2008 Genome Biology 2008 9 236 doi gb-2008-9-10-236 The electronic version of this article is the complete one and can be found online at http 2008 9 10 236 2008 BioMed Central Ltd Abstract Condensin and cohesin are loaded onto yeast chromosomes by a common mechanism at RNA polymerase III transcribed genes. Whereas cohesin translocates from these loading sites to mediate cohesion at secondary locations condensin remains bringing distant sites together into clusters. Structural maintenance of chromosome proteins or SMCs for short are components of a variety of complexes that are central to the organization utilization and segregation of chromosomes 1 . SMCs are unusually large proteins that fold on themselves to form long coiled coils with an ATPase head at one end. A dimerization motif at the other end allows the proteins to form SMC pairs which in turn associate with additional structural and regulatory factors. The Smc1 and Smc3 dimer forms the core of the complex known as cohesin which mediates sister-chromatid cohesion by directly binding sister chromatids together until the onset of anaphase. The Smc2 and Smc4 dimer forms the core of condensin a protein complex that facilitates DNA chromosome condensation in preparation for mitotic segregation. An additional pair of proteins Smc5 and Smc6 forms the core of a less well understood complex with important roles in several critical processes including DNA damage checkpoint response and repair. .

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