TAILIEUCHUNG - Báo cáo sinh học: "Antiviral drugs against hepatitis C virus"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Antiviral drugs against hepatitis C virus | Rehman et al. Genetic Vaccines and Therapy 2011 9 11 http content 9 1 11 REVIEW z GENETIC VACCINES AND THERAPY Open Access Antiviral drugs against hepatitis C virus Sidra Rehman1 Usman A Ashfaq t and Tariq Javed Abstract Hepatitis C virus HCV infection is a major worldwide problem causes acute and chronic HCV infection. Current treatment of HCV includes pegylated interferon-a PEG IFN- a plus ribavirin RBV which has significant side effects depending upon the type of genotype. Currently there is a need to develop antiviral agents both from synthetic chemistry and Herbal sources. In the last decade various novel HCV replication helicase and entry inhibitors have been synthesized and some of which have been entered in different phases of clinical trials. Successful results have been acquired by executing combinational therapy of compounds with standard regime in different HCV replicons. Even though diverse groups of compounds have been described as antiviral targets against HCV via Specifically Targeted Antiviral Therapy for hepatitis C STAT-C approach in which compounds are designed to directly block HCV or host proteins concerned in HCV replication still there is a need to improve the properties of existing antiviral compounds. In this review we sum up potent antiviral compounds against entry unwinding and replication of HCV and discussed their activity in combination with standard therapy. Conclusively further innovative research on chemical compounds will lead to consistent standard therapy with fewer side effects. Introduction HCV belonging to the family Flaviviridae signifies to be an entire global dilemma which parades the variability of genome translated into six genotypes and more than 80 subtypes. HCV has infected 200 million people worldwide 1 of which 10 million individuals 6 of the population have been spotted in Pakistan 2 . HCV was firstly recognized in 1989 3 comprising of kb positive sense genome. It encodes a single .

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