TAILIEUCHUNG - Báo cáo sinh học: " Genetic immunization with Hantavirus vaccine combining expression of G2 glycoprotein and fused interleukin-2"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Genetic immunization with Hantavirus vaccine combining expression of G2 glycoprotein and fused interleukin-2 | Genetic Vaccines and Therapy BioMed Central Research Genetic immunization with Hantavirus vaccine combining expression of G2 glycoprotein and fused interleukin-2 Huang Hao1 3 Li Xiu2 Zhang Zehua1 Jia Min1 Hu Hongbo1 Wu Zhihong1 Zhu Zhenhua1 Wan Xiaohong1 and Huang Hanju 1 Address Department of Pathogentic Biology Tongji Medical College Huazhong University of Science and Technology Wuhan city 430030 PR China 2Department of Health Tongji Medical College Huazhong University of Science and Technology Wuhan city 430030 PR China and 3Center of Experimental Medicine Wuhan first hospital Wuhan city 430022 PR China Email Huang Hao - whhuanghao10@ Li Xiu - hao4@ Zhang Zehua - violet3342@ Jia Min - pollyann@ Hu Hongbo-huhongbo1@ WuZhihong-huanghao10@ Zhu Zhenhua - hao4@ Wan Xiaohong - wuhanhuanghao10@ Huang Hanju - juguangying@ Corresponding author Open Access Published 22 October 2008 Received 29 May 2008 _ I ir J. 1 I mz i z-rz rrz z ir Accepted 22 October 2008 Genetic Vaccines and Therapy 2008 6 15 doi 1479-0556-6-15 This article is available from http content 6 1 15 2008 Hao et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ In this research we developed a novel chimeric HTNV-IL-2-G2 DNA vaccine plasmid by genetically linking IL-2 gene to the G2 segment DNA and tested whether it could be a candidate vaccine. Chimeric gene was first expressed in eukaryotic expression system . The HTNV-IL-2-G2 expressed a 72 kDa fusion protein in COS-7 cells. Meanwhile the fusion protein kept the activity of its parental proteins. .

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