TAILIEUCHUNG - Báo cáo sinh học: " Clostridial spores as live 'Trojan horse' vectors for cancer gene therapy: comparison with viral delivery systems"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Clostridial spores as live 'Trojan horse' vectors for cancer gene therapy: comparison with viral delivery systems | Genetic Vaccines and Therapy BioMed Central Review Open Access Clostridial spores as live Trojan horse vectors for cancer gene therapy comparison with viral delivery systems Ming Q Wei 1 2 Ruimei Ren1 2 3 David Good1 2 and Jozef Anné4 Address Department of Medicine University of Queensland Prince Charles Hospital Brisbane Queensland 4032 Australia 2Division of Molecular and Gene Therapies Griffith Institute for Health and Medical Research GH1 Griffith University Gold Coast Queensland 4222 Australia 3Tumour Hospital Shandong Academy of Medical Sciences Jinan Shandong Province PR China and 4Rega Institute for Medical Research Minderbroedersstraat 10 B-3000 Leuven Belgium Email Ming Q Wei - Ruimei Ren - xiaohui168168@ David Good - Jozef Anné - Corresponding author Published 17 February 2008 Received 21 May 2007 Genetic Vaccines and Therapy 2008 6 8 doi l479-0556-6-8 Accepted I7 February 2008 This article is available from http content 6 1 8 2008 Wei et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Solid tumours account for 90 of all cancers. Gene therapy represents a potential new modality for their treatment. Up to now several approaches have been developed but the most efficient ones are the viral vector based gene therapy systems. However viral vectors suffer from several deficiencies firstly most vectors currently in use require intratumoural injection to elicit an effect. This is far from ideal as many tumours are inaccessible and many may have already spread to other parts of the body making them difficult to locate and inject gene therapy vectors into. Second because of cell heterogeneity within

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