TAILIEUCHUNG - Báo cáo sinh học: " DNA-vaccination via tattooing induces stronger humoral and cellular immune responses than intramuscular delivery supported by molecular adjuvants"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: DNA-vaccination via tattooing induces stronger humoral and cellular immune responses than intramuscular delivery supported by molecular adjuvants | Genetic Vaccines and Therapy BioMed Central Short paper DNA-vaccination via tattooing induces stronger humoral and cellular immune responses than intramuscular delivery supported by molecular adjuvants Dana Pokorna1 Ivonne Rubio2 and Martin Muller 2 Open Access Address Department of Experimental Virology Institute of Hematology and Blood Transfusion Prague Czech Republic and 2Deutsches Krebsforschungszentrum Heidelberg Germany Email Dana Pokorna - Ivonne Rubio - Martin Muller - Corresponding author Published 7 February 2008 Received 9 October 2007 I J. 1 I mz i z-rz rrz z Accepted 7 February 2008 Genetic Vaccines and Therapy 2008 6 4 doi 1479-0556-6-4 This article is available from http content 6 1 4 2008 Pokorna et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Tattooing is one of a number of DNA delivery methods which results in an efficient expression of an introduced gene in the epidermal and dermal layers of the skin. The tattoo procedure causes many minor mechanical injuries followed by hemorrhage necrosis inflammation and regeneration of the skin and thus non-specifically stimulates the immune system. DNA vaccines delivered by tattooing have been shown to induce higher specific humoral and cellular immune responses than intramuscularly injected DNA. In this study we focused on the comparison of DNA immunization protocols using different routes of administrations of DNA intradermal tattoo versus intramuscular injection and molecular adjuvants cardiotoxin pre-treatment or GM-CSF DNA codelivery . For this comparison we used the major capsid

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