TAILIEUCHUNG - Báo cáo sinh học: " HDAC inhibitor valproic acid upregulates CAR in vitro and in vivo"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: HDAC inhibitor valproic acid upregulates CAR in vitro and in vivo | Genetic Vaccines and Therapy BioMed Central Research Open Access HDAC inhibitor valproic acid upregulates CAR in vitro and in vivo Blanca Segura-Pacheco Berenice Avalosh Edgar Rangel Dora Velazquez and Gustavo Cabrera Address Vectorology and Gene Therapy Laboratory National Cancer Institute Av. San Fernando No 22 Del. Tlalpan CP 14080 Mexico City Mexico Email Blanca Segura-Pacheco - segura_blanca@ Berenice Avalos - bjar_fernandez@ Edgar Rangel - raledg@ DoraVelazquez - doris_oscuridad@ Gustavo Cabrera - Corresponding author tEqual contributors Published 24 September 2007 Received 4 May 2007 JTÌ . - -7 I- IAccepted 24 September 2007 Genetic Vaccines and Therapy 2007 5 10 doi 1479-0556-5-10 This article is available from http content 5 1 10 2007 Segura-Pacheco et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The presence of CAR in diverse tumor types is heterogeneous with implications in tumor transduction efficiency in the context of adenoviral mediated cancer gene therapy. Preliminary studies suggest that CAR transcriptional regulation is modulated through histone acetylation and not through promoter methylation. Furthermore it has been documented that the pharmacological induction of CAR using histone deacetylase inhibitor iHDAC compounds is a viable strategy to enhance adenoviral mediated gene delivery to cancer cells in vitro. The incorporation of HDAC drugs into the overall scheme in adenoviral based cancer gene therapy clinical trials seems rational. However reports using compounds with iHDAC properties utilized routinely in the clinic are pending. Valproic acid a short chained fatty acid extensively

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