TAILIEUCHUNG - Báo cáo sinh học: "The use of retroviral vectors for gene therapy-what are the risks? A review of retroviral pathogenesis and its relevance to retroviral vector-mediated gene delivery"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: The use of retroviral vectors for gene therapy-what are the risks? A review of retroviral pathogenesis and its relevance to retroviral vector-mediated gene delivery | Genetic Vaccines and Therapy BioMed Central Review Open Access The use of retroviral vectors for gene therapy-what are the risks A review of retroviral pathogenesis and its relevance to retroviral vector-mediated gene delivery Donald S Anson 1 2 3 Address Department of Genetic Medicine Women s and Children s Hospital 4th Floor Rogerson Building 72 King William Road North Adelaide South Australia 5006 Australia 2Department of Paediatrics University of Adelaide South Australia 5005 Australia and 3Department of Biotechnology Flinders University GPO Box 2100 Adelaide South Australia 5001 Australia Email Donald S Anson - Corresponding author Published 13 August 2004 Received II April 2004 Genetic Vaccines and Therapy 2004 2 9 doi 1479-0556-2-9 Accepted 13 August 2004 This article is available from http content 2 1 9 2004 Anson licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Retroviral vector-mediated gene transfer has been central to the development of gene therapy. Retroviruses have several distinct advantages over other vectors especially when permanent gene transfer is the preferred outcome. The most important advantage that retroviral vectors offer is their ability to transform their single stranded RNA genome into a double stranded DNA molecule that stably integrates into the target cell genome. This means that retroviral vectors can be used to permanently modify the host cell nuclear genome. Recently retroviral vector-mediated gene transfer as well as the broader gene therapy field has been re-invigorated with the development of a new class of retroviral vectors which are derived from lentiviruses. These have the unique ability amongst retroviruses of being

• Báo cáo khoa học
• Báo cáo sinh học hay
• cách trình bày báo cáo
• báo cáo sinh học
• công trình nghiên cứu sinh học
• tài liệu về sinh học