TAILIEUCHUNG - báo cáo hóa học:" PAR1 is selectively over expressed in high grade breast cancer patients: a cohort study"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : PAR1 is selectively over expressed in high grade breast cancer patients: a cohort study | Journal of Translational Medicine BioMed Central Research PAR1 is selectively over expressed in high grade breast cancer patients a cohort study Norma A Hernandez 1 Elma Correa1 Esther P Avila1 Teresa A Vela2 and Victor M Pérez2 Address 1Subdirección de Investigación Básica Instituto Nacional de Cancerología Mexico City Mexico and 2Patología Post-Mortem y Tumores Mamarios Instituto Nacional de Cancerología Mexico City Mexico Email Norma A Hernández - normahernandez21@ Elma Correa - elsy15@ Esther P Avila - akane_217@ Teresa A Vela - terezan2002@ Victor M Pérez - pesv2003@ Corresponding author Open Access Published 18 June 2009 Received 20 January 2009 Journal of Translational Medicine 2009 7 47 doi l479-5876-7-47 Accepted 18 June 2009 This article is available from http content 7 1 47 2009 Hernández et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The protease-activated receptor PAR1 expression is correlated with the degree of invasiveness in cell lines. Nevertheless it has never been directed involved in breast cancer patients progression. The aim of this study was to determine whether PAR1 expression could be used as predictor of metastases and mortality. Methods In a cohort of patients with infiltrating ductal carcinoma studied longitudinally since 1996 and until 2007 PAR1 over-expression was assessed by immunoblotting immunohistochemistry and flow citometry. Chi-square and log rank tests were used to determine whether there was a statistical association between PAR1 overexpression and metastases mortality and survival. Multivariate analysis was performed including HER1 stage ER and nodes status to evaluate PAR1

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