TAILIEUCHUNG - báo cáo hóa học:" Semi-allogeneic vaccines and tumor-induced immune tolerance"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Semi-allogeneic vaccines and tumor-induced immune tolerance | Journal of Translational Medicine BioMed Central Open Access Semi-allogeneic vaccines and tumor-induced immune tolerance Jin Yu1 Mark S Kindy1 3 4 and Sebastiano Gattoni-Celli 2 3 4 Address Department of Neurosciences Medical University of South Carolina Charleston SC 29425 USA 2Department of Radiation Oncology Medical University of South Carolina Charleston SC 29425 USA 3Ralph H. Johnson VA Medical Center Charleston SC 29401 USA and 4SemiAlloGen Inc. 3384 Shagbark Circle Mt. Pleasant SC 29466 USA Email Jin Yu - yujin@ Mark S Kindy - kindyms@ Sebastiano Gattoni-Celli - gattonis@ Corresponding author Published 8 January 2009 Received 17 October 2008 Journal of Translational Medicine 2009 7 3 doi l479-5876-7-3 Accepted 8 January 2009 This article is available from http content 7 1 3 2009 Yu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Experimental results from studies with inbred mice and their syngeneic tumors indicated that the inoculation of semi-allogeneic cell hybrids derived from the fusion between syngeneic tumor cells and an allogeneic cell line protects the animal host from a subsequent lethal challenge with unmodified syngeneic tumor cells. Semi-allogeneic somatic cell hybrids were generated by the fusion of EL-4 T lymphoma cells H-2b and BALB c-derived renal adenocarcinoma RAG cells H- 2d . Cell hybrids were injected intra-peritoneally . in C57BL 6 mice H-2b before challenging the mice with a tumorigenic dose of EL-4 cells. Semi-allogeneic tumor cell hybrids could not form a tumor in the animal host because they expressed allogeneic determinants H-2d and were rejected as a transplant. However they conferred protection against a .

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