TAILIEUCHUNG - Báo cáo y học: "s mammalian chromosomal evolution driven by regions of genome fragility"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Is mammalian chromosomal evolution driven by regions of genome fragility? | Open Access Research Is mammalian chromosomal evolution driven by regions of genome fragility Aurora Ruiz-Herrera Jose Castresana and Terence J Robinson Addresses Evolutionary Genomics Group Department of Botany Zoology University of Stellenbosch Private Bag X1 Matieland 7602 South Africa. fInstitut de Biologia Molecular de Barcelona CSIC Department of Physiology and Molecular Biodiversity Jordi Girona 18 08034 Barcelona Spain. Correspondence Terence J Robinson. Email tjr@ Published 8 December 2006 Genome Biology 2006 7 R115 doi gb-2006-7- 12-r115 The electronic version of this article is the complete one and can be found online at http 2006 7 12 R1 15 Received 1 August 2006 Revised 6 November 2006 Accepted 8 December 2006 2006 Ruiz-Herrera et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background A fundamental question in comparative genomics concerns the identification of mechanisms that underpin chromosomal change. In an attempt to shed light on the dynamics of mammalian genome evolution we analyzed the distribution of syntenic blocks evolutionary breakpoint regions and evolutionary breakpoints taken from public databases available for seven eutherian species mouse rat cattle dog pig cat and horse and the chicken and examined these for correspondence with human fragile sites and tandem repeats. Results Our results confirm previous investigations that showed the presence of chromosomal regions in the human genome that have been repeatedly used as illustrated by a high breakpoint accumulation in certain chromosomes and chromosomal bands. We show however that there is a striking correspondence between fragile site location the positions of evolutionary breakpoints and the

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