TAILIEUCHUNG - Báo cáo y học: "An inventory of yeast proteins associated with nucleolar and ribosomal components"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: An inventory of yeast proteins associated with nucleolar and ribosomal components. | Open Access Research An inventory of yeast proteins associated with nucleolar and ribosomal components Eike Staub Sebastian Mackowiak and Martin Vingron Address Department of Computational Molecular Biology Max Planck Institute for Molecular Genetics Berlin Germany. Correspondence Eike Staub. Email Published 26 October 2006 Genome Biology 2006 7 R98 doi gb-2006-7-1 0-r98 The electronic version of this article is the complete one and can be found online at http 2006 7 10 R98 2006 Staub et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Received 18 May 2006 Revised 26 July 2006 Accepted 26 October 2006 Abstract Background Although baker s yeast is a primary model organism for research on eukaryotic ribosome assembly and nucleoli the list of its proteins that are functionally associated with nucleoli or ribosomes is still incomplete. We trained a naive Bayesian classifier to predict novel proteins that are associated with yeast nucleoli or ribosomes based on parts lists of nucleoli in model organisms and large-scale protein interaction data sets. Phylogenetic profiling and gene expression analysis were carried out to shed light on evolutionary and regulatory aspects of nucleoli and ribosome assembly. Results We predict that in addition to 439 known proteins a further 62 yeast proteins are associated with components of the nucleolus or the ribosome. The complete set comprises a large core of archaeal-type proteins several bacterial-type proteins but mostly eukaryote-specific inventions. Expression of nucleolar and ribosomal genes tends to be strongly co-regulated compared to other yeast genes. Conclusion The number of proteins associated with nucleolar or ribosomal .

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