TAILIEUCHUNG - Báo cáo y học: "Unraveling transcriptional control and cis-regulatory codes using the software suite GeneACT"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Unraveling transcriptional control and cis-regulatory codes using the software suite GeneACT. | Open Access Software Unraveling transcriptional control and cis-regulatory codes using the software suite GeneACT Tom Hiu Cheung Yin Lam Kwan Micah Hamady and Xuedong Liu Addresses Department of Chemistry and Biochemistry University of Colorado 215 UCB Boulder Colorado 80309 USA. Department of Computer Science University of Colorado 430 UCB Boulder Colorado 80309 USA. Correspondence Xuedong Liu. Email Published 25 October 2006 Genome Biology 2006 7 R97 doi gb-2006-7-l 0-r97 The electronic version of this article is the complete one and can be found online at http 2006 7 10 R97 Received 16 June 2006 Revised 18 September 2006 Accepted 25 October 2006 2006 Cheung et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Deciphering gene regulatory networks requires the systematic identification of functional c s-acting regulatory elements. We present a suite of web-based bioinformatics tools called GeneACT http that can rapidly detect evolutionarily conserved transcription factor binding sites or microRNA target sites that are either unique or over-represented in differentially expressed genes from DNA microarray data. GeneACT provides graphic visualization and extraction of common regulatory sequence elements in the promoters and 3 -untranslated regions that are conserved across multiple mammalian species. Rationale Cell type and tissue specific gene expression patterns are primarily governed by the cis-regulatory sequence elements embedded in the noncoding regions of the genome. These cis-regulatory elements are often recognized in a sequence-specific manner by regulatory proteins or nucleic acids which regulate the expression of the corresponding

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