TAILIEUCHUNG - Báo cáo y học: "Signals and systems"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Signals and systems. | Meeting report Signals and systems Nevan J Krogan and Timothy R Hughes Addresses Department of Cellular and Molecular Pharmacology University of California San Francisco CA 94143 USA. Banting and Best Department of Medical Research University of Toronto Toronto ON M5S 3E1 Canada. Correspondence Timothy R Hughes. Email Published 25 April 2006 Genome Biology 2006 7 313 doi gb-2006-7-4-313 The electronic version of this article is the complete one and can be found online at http 2006 7 4 313 2006 BioMed Central Ltd A report on the 2006 Keystone Conference on Signaling Networks Vancouver Canada 30 January-4 February 2006. The boundaries between traditional notions of cellular signaling and more genomic and systematic approaches to biology are becoming increasingly blurred and the recent Keystone conference on signaling networks reflected an expanded view of signaling. It is becoming increasingly accepted that genes proteins cells and organisms function as components of larger systems rather than independent activities contributing to a single defined outcome and many presentations at the conference reflected this. If there was a single theme it was the heavy reliance on technical approaches in functional genomics proteomics and computational biology such that conceptual and technical discussions often dominated the resulting biology. RNA interference screening The impact of technology on the study of signaling networks was most evident in the widespread application of RNA interference RNAi screens. Screens to study signaling networks in multicellular organisms using RNAi technology are being performed with success although several hurdles clearly remain. One of these is the apparently high rate of false positives. In his keynote lecture Norbert Perrimon Harvard Medical School Boston USA predicted an uncomfortably high rate of false positives due to off-target effects at least in Drosophila. Consistent with this Phil Beachy

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