TAILIEUCHUNG - Báo cáo sinh học : " Notch signaling, the segmentation clock, and the patterning of vertebrate somites"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Notch signaling, the segmentation clock, and the patterning of vertebrate somites. | Journal of Biology BloMed Central Review Notch signaling the segmentation clock and the patterning of vertebrate somites Julian Lewis Anja Hanisch and Maxine Holder Address Vertebrate Development Laboratory Cancer Research UK London Research Institute 44 Lincoln s Inn Fields London WC2A 3PX UK. Correspondence Julian Lewis. Email Published 22 May 2009 Journal of Biology 2009 8 44 doi jbiol145 The electronic version of this article is the complete one and can be found online at http content 8 4 44 2009 BioMed Central Ltd Abstract The Notch signaling pathway has multifarious functions in the organization of the developing vertebrate embryo. One of its most fundamental roles is in the emergence of the regular pattern of somites that will give rise to the musculoskeletal structures of the trunk. The parts it plays in the early operation of the segmentation clock and the later definition and differentiation of the somites are beginning to be understood. In one way or another at one stage or another almost every tissue in an animal body depends for its patterning on the Notch cell-cell signaling pathway 1 . The evidence from mutants is clear disrupted Notch signaling entails disrupted pattern. The challenge is to define precisely what it is that Notch signaling does in any given case and when it does it. This problem is posed in a particularly striking and curious way by the phenomena of somitogenesis - the process by which the vertebrate embryo lays down the regular sequence of tissue blocks that will give rise to the musculoskeletal segments of the neck trunk and tail. These blocks of embryonic tissue the somites are arranged symmetrically in a neat repetitive pattern on either side of the central body axis. Each somite is separated from the next by a cleft - the segment boundary and each somite has a definite polarity with an anterior portion and posterior portion expressing different sets of genes 2 . Mutations in .

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