TAILIEUCHUNG - Báo cáo sinh học: "Regeneration review reprise"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Regeneration review reprise. | Whited and Tabin Journal of Biology 2010 9 15 http content 9 2 15 Journal of Biology MINIREVIEW L__ Regeneration review reprise Jessica L Whited and Clifford J Tabin See research articles http 1741-7007 7 83 and http 1741-7007 8 5 Abstract There have been notable advances in the scientific understanding of regeneration within the past year alone including two recently published in BMC Biology. Increasingly progress in the regeneration field is being inspired by comparisons with stem cell biology and enabled by newly developed techniques that allow simultaneous examination of thousands of genes and proteins. Regeneration of complex structures such as appendages has long fascinated and perplexed biologists. Historically understanding regeneration has been approached often to great effect through surgical operations grafting dissections and other tools borrowed from embryologists. More recently additional insights have been gleaned through analyzing appendage development genes during regeneration. Now rather than simply investigating the potential roles of genes already known to be important in the context of the embryonic development of a structure researchers are using modern techniques to interrogate gene transcription and protein translation during various stages of regeneration itself 1-4 . In addition new clues are being drawn from other areas of biology to tackle longstanding regeneration questions 1 2 5 . A year ago we 6 provided a general outline of the morphological events accompanying limb regeneration and a summary of the classical experiments that provided some of the most salient principles of regeneration these aspects are therefore not extensively reviewed here. Instead the focus is on what has been learned within the past year and what discoveries might be awaiting fresh perspectives and tools on the horizon. Correspondence tabin@ Department of Genetics Harvard .

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