TAILIEUCHUNG - Báo cáo sinh học : "Reconstructing prokaryotic transcriptional regulatory networks: lessons from actinobacteria"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Reconstructing prokaryotic transcriptional regulatory networks: lessons from actinobacteria. | Journal of Biology BioMed Central Minireview Reconstructing prokaryotic transcriptional regulatory networks lessons from actinobacteria Thiago M Venancio and L Aravind Address National Center for Biotechnology Information National Library of Medicine National Institutes of Health Bethesda Maryland 20894 USA. Correspondence L Aravind. Email aravind@ Published 15 April 2009 Journal of Biology 2009 8 29 doi jbiol132 The electronic version of this article is the complete one and can be found online at http content 8 3 29 2009 BioMed Central Ltd Abstract Reconstruction of transcriptional regulatory networks of uncharacterized bacteria is a main challenge for the post-genomic era. Recent studies including one in BMC Systems Biology address this problem in the relatively underexplored actinobacteria clade which includes major pathogenic and economically relevant taxa. Transcription regulatory networks Since the pioneering work of Jacob and Monod 1 nearly half a century ago which led to the operon model of prokaryotic gene regulation genetic and molecular studies have deciphered the regulatory processes for a significant fraction of the genome of Escherichia coli. In the same period Bacillus subtilis too has risen to the status of a major model bacterium thereby providing us with glimpses of gene regulation in two far-flung branches of the bacterial evolutionary tree. A primary outcome of these studies has been the identification of general or basal transcription factors such as sigma factors and specific transcription factors such as the lac operon repressor lacI that together mediate the expression of target genes by binding specific regulatory DNA sequences called transcription factor binding sites Figure 1a 2 . Accumulation of such data in model organisms on a genomic scale has recently allowed representation of these regulatory interactions between transcription factors and their target genes as an ordered graph or a network. This .

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