TAILIEUCHUNG - Báo cáo sinh học: "The long term effects of chemotherapy on the central nervous system"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: The long term effects of chemotherapy on the central nervous system. | J. Biol. Journal of Biology BioMed Central Minireview The long term effects of chemotherapy on the central nervous system Patricia K Duffner Address Department of Neurology Women and Children s Hospital of Buffalo University of Buffalo School of Medicine 219 Bryant St. Buffalo NY 14222 USA. Email PatriciaDuffner@ Published 30 November 2006 Journal of Biology 2006 5 21 The electronic version of this article is the complete one and can be found online at http content 5 7 21 2006 BioMed Central Ltd Abstract Cranial radiotherapy is known to have adverse effects on intelligence. A new study shows that chemotherapy is also toxic to the central nervous system especially to neural progenitor cells and oligodendrocytes. By identifying the cell populations at risk these results may help explain the neurological problems previously seen after chemotherapy. Although the long-term effects of irradiation on the central nervous system CNS are now well-known and accepted the long term consequences of most chemotherapeutic agents have rarely been considered either in the development of multi-institutional cancer group studies or in the follow-up of survivors. In this issue of Journal of Biology Mark Noble and colleagues 1 describe an interesting and important series of experiments that helps define the cellular basis for cognitive decline and white matter diseases leukoencephalopathy in patients treated with chemotherapy. Noble and colleagues 1 have now shown that standard chemotherapeutic agents given in dosages comparable to those used in the clinical arena are even more toxic to CNS progenitor cells and oligodendrocytes than they are to cancer cell lines causing both decreased cell division and cell death. The authors conducted four groups of experiments. In the first DNA cross-linking agents - 1 3-bis 2-chlorethyl -1-nitrosourea BCNU and cisplatin CDDP - were applied in vitro to purified populations of neuroepthelial stem cells neural-restricted precursor cells

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