TAILIEUCHUNG - Báo cáo sinh học: "The interaction map of yeast: terra incognit"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài:The interaction map of yeast: terra incognita? | J. Biol. Journal of Biology BioMed Central Minireview The interaction map of yeast terra incognita Joe Mellor and Charles DeLisi Address Program in Bioinformatics 24 Cummington Street Boston University Boston MA 02215 USA. Correspondence Joe Mellor. Email mellor@ Published 8 June 2006 Journal of Biology 2006 5 10 The electronic version of this article is the complete one and can be found online at http content 5M 10 2006 BioMed Central Ltd Abstract A systematic curation of the literature on Saccharomyces cerevisiae has yielded a comprehensive collection of experimentally observed interactions. This new resource augments current views of the topological structure of yeast s physical and genetic networks but also reveals that existing studies cover only a fraction of the cell. Biologists today find themselves in a situation not unlike that of 15th-century explorers. Roughly half a millennium ago an era of exploration stemmed from a need for better information and more precise maps to facilitate new commerce. Novel technologies including faster ships and improved navigation facilitated exploration. The one-to-many communication made possible by the printing press accelerated the impact of these new discoveries and our views of the planet and of ourselves were both revolutionized. In our own time technology pushes biology towards equally revolutionary breakthroughs. The fundamental purpose - deeper understanding and improvement of life - remains the same now as then although the details methods and goals are of course vastly different. The sequencing of hundreds of genomes the systematic measurements of genome activity the large-scale assays of protein-protein and protein-DNA binding and the use of computers to analyze information and facilitate many-to-many communication collectively promise an unprecedented understanding of the workings of the cell and a revolution in medicine. The advent of high-throughput biology allows us for the first time in .

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