TAILIEUCHUNG - Báo cáo sinh học: "Research news Tracking evolution’s footprints in the genome"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Research news Tracking evolution’s footprints in the genome. | J. Biol. Journal of Biology BioMed Central Research news Tracking evolution s footprints in the genome Jonathan B Weitzman Published 23 June 2003 Journal of Biology 2003 2 9 The electronic version of this article is the complete one and can be found online at http content 2 2 9 2003 BioMed Central Ltd The strategy of using phylogenetic footprinting to find regulatory sites that are conserved between pairs of related complex genomes has led to the development of a suite of computational tools that succeed in finding functionally important transcription-factor-binding sequences. Celebrating the latest completed genome sequencing project is all very well but even before the champagne runs dry questions are asked about how best to use all the sequence information. The observation that less than 2 of the human genome sequence actually encodes proteins is a sobering issue for the post-genomic era . And finding functionally relevant information within the non-coding sequence presents a formidable challenge akin to tracking footprints in a dense forest. In this issue of the Journal of Biology 1 Boris Lenhard Albin Sandelin Wyeth Wasserman and colleagues describe a computational approach that will benefit all researchers keen to locate and explore the regulatory elements in their chosen genome see The bottom line box for a summary of their work . Predicting binding sites Understanding the principles that govern where and when genes are expressed is essential for deciphering how genome information is turned into the molecular and cellular phenomena that underlie the biology of complex organisms. Gene expression programs are determined through the recognition of specific promoter and enhancer sequences within the DNA by regulatory transcription-factor proteins. Transcription-factor-binding sites TFBSs see the Background box are short sequences many of which have been painstakingly elucidated over the years using experimental procedures such as DNAse footprinting The

• Báo cáo khoa học
• Báo cáo sinh học hay
• cách trình bày báo cáo
• báo cáo sinh học
• công trình nghiên cứu sinh học
• tài liệu về sinh học