TAILIEUCHUNG - Báo cáo y học: "An evolutionary and functional assessment of regulatory network motifs"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: An evolutionary and functional assessment of regulatory network motifs. | Research Open Access An evolutionary and functional assessment of regulatory network motifs Aurélien Mazurie Samuel Bottani and Massimo Vergassola Addresses Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs CNRS UMR 7091 CERVI La Pitié 91-105 boulevard de l Hopital 75013 Paris France. ỶGroupe de Modélisation Physique Interfaces Biologie and CNRS-UMR 7057 Matières et Systèmes Complexes Université Paris 7 2 place Jussieu 75251 Paris Cedex 05 France. Unité Génomique des Microorganismes Pathogènes CNRS URA 2171 Department of the Structure and Dynamics of Genomes Institut Pasteur 28 rue du Dr Roux F-75724 Paris Cedex 15 France. Correspondence Samuel Bottani. E-mail bottani@ Published 24 March 2005 Genome Biology 2005 6 R35 doi 186 gb-2005-6-4-r35 The electronic version of this article is the complete one and can be found online at http 2005 6 4 R35 Received 19 October 2004 Revised 31 December 2004 Accepted 22 February 2005 2005 Mazurie et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Cellular functions are regulated by complex webs of interactions that might be schematically represented as networks. Two major examples are transcriptional regulatory networks describing the interactions among transcription factors and their targets and proteinprotein interaction networks. Some patterns dubbed motifs have been found to be statistically over-represented when biological networks are compared to randomized versions thereof. Their function in vitro has been analyzed both experimentally and theoretically but their functional role in vivo that is within the full network and the resulting evolutionary pressures remain largely to

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