TAILIEUCHUNG - Báo cáo khoa học: RNF13: an emerging RING finger ubiquitin ligase important in cell proliferation

Protein ubiquitination mediated by ubiquitin ligases plays a very important role in a wide spectrum of biological processes including development and disease pathogenesis. RING finger protein 13 (RNF13) is a recently identi-fied ubiquitin ligase which contains an N-terminal protease-associated domain and a C-terminal RING finger domain separated by a transmem-brane region. | 1FEBS Journal MINIREVIEW RNF13 an emerging RING finger ubiquitin ligase important in cell proliferation Xianglan Jin1 2 He Cheng1 Jie Chen2 and Dahai Zhu1 1 NationalLaboratory of MedicalMolecular Biology Tsinghua University Beijing China 2 Department of Pathology Peking Union MedicalCollege Hospital Tsinghua University Beijing China Keywords cancer development differentiation E3 ubiquitin ligase myogenesis neurogenesis proliferation RING finger domain RNF13 ubiquitination Correspondence D. Zhu NationalLaboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Peking Union MedicalCollege Tsinghua University 5 Dong Dan San Tiao Beijing 100005 China Fax 86 10 6510 5083 Tel 86 10 6529 6949 E-mail dhzhu@ or dhzhusara@ Protein ubiquitination mediated by ubiquitin ligases plays a very important role in a wide spectrum of biological processes including development and disease pathogenesis. RING finger protein 13 RNF13 is a recently identified ubiquitin ligase which contains an N-terminal protease-associated domain and a C-terminal RING finger domain separated by a transmembrane region. RNF13 is an evolutionarily conserved protein. Most interestingly RNF13 expression is developmentally regulated during myogenesis and is upregulated in various human tumors. These data suggest that RNF13 acting as an ubiquitin ligase might have profound biological functions during development and disease. This minireview summarizes recent work on RNF13 functions related to cell proliferation differentiation and cancer development. Received 15 April 2010 revised 13 September 2010 accepted 12 October 2010 doi Introduction The classic function of the 76-amino acid globular polypeptide termed ubiquitin involves participation in post-translational modification of proteins prior to proteolytic degradation in the 26S proteasome complex. The ubiquitin ligase E3 enzyme acts in concert with .

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