TAILIEUCHUNG - Biomedical Engineering 2012 Part 11

Tham khảo tài liệu 'biomedical engineering 2012 part 11', kỹ thuật - công nghệ, cơ khí - chế tạo máy phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | 392 Biomedical Engineering and circular coil measurement with a numerical simulation has been explored. The results reveal that the location of the haematoma has a substantial effect on the sensitivity of the magnetron and circular coils. Furthermore we find that at certain different frequencies the various locations of the haematomas produce no volumetric phase shift. Rojas et al 2008 . Those changes in the spectra of inductive phase shift are expected to be amplified by the use of magnetic nanoparticles coupled to tumoural cells. Theoretical fundaments of MIS assisted by magnetic nanostructures i. Selective coupling of bioconjugated nanoparticles The selective coupling principle of bioconjugated nanoparticles to tumoural cells is based on the union of magnetic nanoparticles to molecular ligands with affinity to specific bioreceptors in tumoural cells. Specifically the covalent union of magnetic nanoparticles to monoclonal antibodies bioconjugated nanoparticle-antibody has been proposed as cancer markers. To create bioconjugated nanostructures the use of magnetic nanoparticles with magnetite nucleus Fe3O4 and polisacaride coat with functional carboxyl groups has been chosen. The typical diameters are in the order of 50 to 300 nm and have superparamagnetic properties. The ligand of the bioconjugated corresponds to monoclonal antibodies with amino functional groups activated by carbodimine. Carbodimine reacts with carboxyl groups of the magnetic nanoparticles to produce O-acilurea and amino ligand reactions. These reactions produce a covalent union that warrants a stable coupling of the magnetic nanoparticle to the antibody. Figure 1 shows schematically a representation of the principle of the covalent union by carboxyl groups of magnetic nanoparticles and its ligand given by a monoclonal antibody. The bioconjugated nanoparticle-antibody is added to the cell membrane by a non-covalent union created between the antibody and its receptor biomarker in the cell .

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