TAILIEUCHUNG - Báo cáo sinh học: " Linkage disequilibrium and the genetic distance in livestock populations: the impact of inbreeding"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Linkage disequilibrium and the genetic distance in livestock populations: the impact of inbreeding | Genet. Sel. Evol. 36 2004 281-296 INRA EDP Sciences 2004 DOI gse 2004002 281 Original article Linkage disequilibrium and the genetic distance in livestock populations the impact of inbreeding Jérémie Nsengimana Philippe V. Baret Unité de génétique Faculté d ingénierie biologique agronomique et environnementale Université catholique de Louvain Croix du sud 2 box 14 1348 Louvain-la-Neuve Belgium Received 21 March 2003 accepted 22 January 2004 Abstract - Genome-wide linkage disequilibrium LD is subject to intensive investigation in human and livestock populations since it can potentially reveal aspects of a population history permit to date them and help in fine-gene mapping. The most commonly used measure of LD between multiallelic loci is the coefficient D . Data based on D were recently published in humans livestock and model animals. However the properties of this coefficient are not well understood. Its sampling distribution and variance has received recent attention but its expected behaviour with respect to genetic or physical distance remains unknown. Using stochastic simulations of populations having a finite size we show that D fits an exponential function having two parameters of simple biological interpretation the residual value rs towards which D tends as the genetic distance increases and the distance R at which this value is reached. Properties of this model are evaluated as a function of the inbreeding coefficient F . It was found that R and rs increase when F increases. The proposed model offers opportunities to better understand the patterns and the origins of LD in different populations and along different chromosomes. Linkage disequilibrium livestock inbreeding genetic distance exponential function 1. INTRODUCTION Linkage or gametic disequilibrium is useful in revealing past genetically important events in dating them and in fine-gene mapping 1 2 4 8 . However the relationship between linkage disequilibrium LD and the genetic distance in .

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