TAILIEUCHUNG - Báo cáo sinh học: "QTL detection and allelic effects for growth and fat traits in outbred pig populations"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: QTL detection and allelic effects for growth and fat traits in outbred pig populations | Genet. Sel. Evol. 36 2004 83-96 INRA EDP Sciences 2004 DOI gse 2003052 83 Original article QTL detection and allelic effects for growth and fat traits in outbred pig populations Yoshitaka NAGAMiNEa Peter M. VisscHERb Chris S. HALEYa a Roslin Institute Edinburgh Midlothian EH25 9PS UK b Institute of Cell Animal and Population Biology University of Edinburgh West Mains Road Edinburgh EH9 3JT UK Received 17 February 2003 accepted 25 September 2003 Abstract - Quantitative trait loci QTL for growth and fatness traits have previously been identified on chromosomes 4 and 7 in several experimental pig populations. The segregation of these QTL in commercial pigs was studied in a sample of 2713 animals from five different populations. Variance component analysis VCA using a marker-based identity by descent IBD matrix was applied. The IBD coefficient was estimated with simple deterministic SMD and Markov chain Monte Carlo MCMC methods. Data for two growth traits average daily gain on test and whole life daily gain and back fat thickness were analysed. With both methods seven out of 26 combinations of population chromosome and trait were significant. Additionally QTL genotypic and allelic effects were estimated when the QTL effect was significant. The range of QTL genotypic effects in a population varied from to of the phenotypic mean for growth traits and to for back fat trait. Heritabilities of the QTL genotypic values ranged from to for growth traits and to for back fat. Very similar results were obtained with both SMD and MCMC. However the MCMC method required a large number of iterations and hence computation time especially when the QTL test position was close to the marker. QTL mapping IBD variance component heritability pig 1. INTRODUCTION Following the first genome scan for QTL in F2 animals from a cross between wild boar and domestic pig 2 14 numerous studies were performed to locate QTL in pigs 4 18 24 . However almost .

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