TAILIEUCHUNG - dung môi NMP phần 3

N-Methyl-2-pyrrolidone Trong một nghiên cứu độc tính phát triển, 15 con thỏ mang thai cho mỗi cấp độ liều được cho tiếp xúc hàng ngày bằng cách ứng dụng da để 0, 100, 300, hoặc 1000 mg trọng lượng cơ thể NMP / kg đối với 6 giờ / ngày vào ngày 19/07sau thụ tinh. Liều lượng ứng dụng được thực hiện như dung dịch nước 40%. Không có dấu hiệu độc tính mẹ. | N-Methyl-2-pyrrolidone In a developmental toxicity study 15 pregnant rabbits per dose level were exposed daily by dermal application to 0 100 300 or 1000 mg NMP kg body weight for 6 h day on days 7-19 post-insemination. The application doses were made as 40 aqueous solution. There were no signs of maternal toxicity. At 1000 mg kg body weight per day a slight fetal toxicity was seen as increased occurrence of skeletal variation accessory 13th ribs BASF 1993a . An intraperitoneal daily dose to mice of 0 630 or 1570 mg kg body weight on days 11-15 of gestation caused increased resorption rate increased incidence of runts diminished fetal weight and length and an increased rate of malformations such as cleft palate at the high level. No maternal toxicity was observed. The low dose level caused no observable embryotoxicity. No information on maternal toxicity is given in this study thus evaluation of the results is difficult US EPA 1988 . NMP doses of 14-166 mg kg body weight singly or repeatedly intraperitoneally administered to mice during various phases of pregnancy caused increased post-implantation loss and a reduced body weight of the fetuses. Morphological defects such as exencephaly open eyelids microphthalmia cleft palate oligodactyly shortened or kinked tails fusions and curvature of neck and chest vertebrae and fusion of sternebrae and ribs were observed. The LOAEL for repeated doses was 74 mg kg body weight administered on days 7-11 of gestation. No information on maternal toxicity is given in this study thus evaluation of the results is difficult Schmidt 1976 . Immunological and neurological effects Effects on the immune system thymic atrophy in female rats decreased leukocyte count in both sexes have been described in studies performed in rats after a 28-day oral administration at high dose levels see section . 9. EFFECTS ON HUMANS development however at week 25 signs of delayed fetal development were observed and at week 31 a stillborn fetus was .

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