TAILIEUCHUNG - Báo cáo sinh học: " NNAT and DIRAS3 genes are paternally expressed in pigs"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: NNAT and DIRAS3 genes are paternally expressed in pigs | Genet. Sel. Evol. 39 2007 599-607 Available online at INRA EDP Sciences 2007 DOI gse 2007024 Original article NNAT and DIRAS3 genes are paternally expressed in pigs Huan-Chen CHENGa Feng-Wei Zhanga Chang-Yan DENGa Cao-De JlANGb Yuan-Zhu XlONGa Feng-E Lla Ming-Gang LEIa a Key Laboratory of Agricultural Animal Genetics Breeding and Reproduction of Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture Huazhong Agriculture University Wuhan P R. China b Department of Bio-engineering College of Animal Sciences Southwest University Chongqing 400716 P R. China Received 24 December 2006 accepted 25 April 2007 Abstract - Although expression and epigenetic differences of imprinted genes have been extensively characterised in man and the mouse little is known on livestock species. In this study the polymorphism-based approach was used to detect the imprinting status of NNAT and DIRAS3 genes in five heterozygous pigs based on SNP of Large White and Meishan F1 hybrids. The results show that both genes were paternally expressed in all the tested tissues heart liver spleen lung kidney stomach small intestine skeletal muscle fat uterus ovary and pituitary . In addition the NNAT gene had two transcripts in all tested tissues which is consistent with its counterpart in man and cattle. pig NNAT DIRAS3 imprinting paternally expressed 1. INTRODUCTION Genomic imprinting is a parent-of-origin-dependent epigenetic mechanism in which a subset of autosomal genes is expressed from only one allele 15 . Imprinted genes have important roles in the regulation of foetal growth development function of the placenta and postnatal behaviour in mammals in particular 14 . At present more than 120 imprinted genes have been identified in man and mice but only ten imprinted genes have been identified in sheep seven in cattle and three in pigs http . Therefore it is of interest to identify other imprinted .

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