TAILIEUCHUNG - Báo cáo sinh học: " Epistatic QTL pairs associated with meat quality and carcass composition traits in a porcine Duroc × Pietrain population"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học quốc tế đề tài: Epistatic QTL pairs associated with meat quality and carcass composition traits in a porcine Duroc × Pietrain population | GroBe-Brinkhaus et al. Genetics Selection Evolution 2010 42 39 http content 42 1 39 GSE Ge n et i cs Selection Evolution RESEARCH Open Access Epistatic QTL pairs associated with meat quality and carcass composition traits in a porcine Duroc X Pietrain population 1 1 1 Christine GroBe-Brinkhaus Elisabeth Jonas Heiko Buschbell Chirawath Phatsara Dawit Tesfaye 1 1 1 1 Heinz Jungst Christian Looft Karl Schellander Ernst Tholen Abstract Background Quantitative trait loci QTL analyses in pig have revealed numerous individual QTL affecting growth carcass composition reproduction and meat quality indicating a complex genetic architecture. In general statistical QTL models consider only additive and dominance effects and identification of epistatic effects in livestock is not yet widespread. The aim of this study was to identify and characterize epistatic effects between common and novel QTL regions for carcass composition and meat quality traits in pig. Methods Five hundred and eighty five F2 pigs from a Duroc X Pietrain resource population were genotyped using 131 genetic markers microsatellites and SNP spread over the 18 pig autosomes. Phenotypic information for 26 carcass composition and meat quality traits was available for all F2 animals. Linkage analysis was performed in a two-step procedure using a maximum likelihood approach implemented in the QxPak program. Results A number of interacting QTL was observed for different traits leading to the identification of a variety of networks among chromosomal regions throughout the porcine genome. We distinguished 17 epistatic QTL pairs for carcass composition and 39 for meat quality traits. These interacting QTL pairs explained up to 8 of the phenotypic variance. Conclusions Our findings demonstrate the significance of epistasis in pigs. We have revealed evidence for epistatic relationships between different chromosomal regions confirmed known QTL loci and connected regions reported in other .

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