TAILIEUCHUNG - Báo cáo sinh học: "A microsatellite-based analysis for the detection of selection on BTA1 and BTA20 in northern Eurasian cattle (Bos taurus) populations"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học quốc tế đề tài: A microsatellite-based analysis for the detection of selection on BTA1 and BTA20 in northern Eurasian cattle (Bos taurus) populations | Li et al. Genetics Selection Evolution 2010 42 32 http content 42 1 32 Ge n et i cs Selection Evolution RESEARCH Open Access A microsatellite-based analysis for the detection of selection on BTA1 and BTA20 in northern Eurasian cattle Bos taurus populations Meng-Hua Li Terhi Iso-Touru Hannele Laurén Juha Kantanen Abstract Background Microsatellites surrounding functionally important candidate genes or quantitative trait loci have received attention as proxy measures of polymorphism level at the candidate loci themselves. In cattle selection for economically important traits is a long-term strategy and it has been reported that microsatellites are linked to these important loci. Methods We have investigated the variation of seven microsatellites on BTA1 Bos taurus autosome 1 and 16 on BTA20 using bovine populations of typical production types and horn status in northern Eurasia. Genetic variability of these loci and linkage disequilibrium among these loci were compared with those of 28 microsatellites on other bovine chromosomes. Four different tests were applied to detect molecular signatures of selection. Results No marked difference in locus variability was found between microsatellites on BTA1 BTA20 and the other chromosomes in terms of different diversity indices. Average D values of pairwise syntenic markers and across BTA 1 and BTA20 respectively were significantly P higher than for non-syntenic markers . The Ewens-Watterson test the Beaumont and Nichol s modified frequentist test and the Bayesian FST-test indicated elevated or decreased genetic differentiation at SOD1 and AGLA17 markers respectively deviating significantly P from neutral expectations. Furthermore lnRV lnRH and lnR9 statistics were used for the pairwise population comparison tests and were significantly less variable in one population relative to the other providing additional evidence of selection signatures for two of the 51 loci. Moreover the .

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