TAILIEUCHUNG - Báo cáo sinh học: " Evolution of the polymorphism at molecular markers in QTL and non-QTL regions in selected chicken lines (Open Access publication)"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học quốc tế đề tài: Evolution of the polymorphism at molecular markers in QTL and non-QTL regions in selected chicken lines (Open Access publication) | Genet. Sel. Evol. 40 2008 639-661 INRA EDP Sciences 2008 DOI gse 2008025 Available online at Original article Evolution of the polymorphism at molecular markers in QTL and non-QTL regions in selected chicken lines Open Access publication Valerie Loywyck1 Bertrand Bed hom1 Marie-Hélène Pinard-van DER Laan1 Frederique Pitel2 Etienne Verrier1 Piter Bijma3 1Genetique et Diversite Animales UMR1236 INRA AgroParisTech 78352 Jouy-en-Josas France 2Genetique Cellulaire UR444 INRA 31326 Castanet-Tolosan France 3Animal Breeding and Genomics Group Wageningen University 6700 AH Wageningen The Netherlands Received 22 October 2007 accepted 18 June 2008 Abstract - We investigated the joint evolution of neutral and selected genomic regions in three chicken lines selected for immune response and in one control line. We compared the evolution of polymorphism of 21 supposedly neutral microsatellite markers versus 30 microsatellite markers located in seven quantitative trait loci QTL regions. Divergence of lines was observed by factor analysis. Five supposedly neutral markers and 12 markers in the QTL regions showed Fst values greater than . However the non-significant difference P between matrices of genetic distances based on genotypes at supposedly neutral markers on the one hand and at markers in QTL regions on the other hand showed that none of the markers in the QTL regions were influenced by selection. A supposedly neutral marker and a marker located in the QTL region on chromosome 14 showed temporal variations in allele frequencies that could not be explained by drift only. Finally to confirm that markers located in QTL regions on chromosomes 1 7 and 14 were under the influence of selection simulations were performed using haplotype dropping along the existing pedigree. In the zone located on chromosome 14 the simulation results confirmed that selection had an effect on the evolution of polymorphism of markers within the zone. selection .

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