TAILIEUCHUNG - Báo cáo sinh học: "Prion gene (PRNP) haplotype variation in United States goat breeds (Open Access publication)"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học quốc tế đề tài: Prion gene (PRNP) haplotype variation in United States goat breeds (Open Access publication) | Genet. Sel. Evol. 40 2008 553-561 INRA EDP Sciences 2008 DOI gse 2008021 Available online at Original article Prion gene PRNP haplotype variation in United States goat breeds Open Access publication Stephen White1 2 Lynn Herrmann-Hoesing1 2 Katherine O Rourke1 2 Daniel Waldron3 Joan Rowe4 Janet Alverson1 2 1USDA ARS Animal Disease Research Unit Pullman WA 99164 USA 2Department of Veterinary Microbiology and Pathology Washington State University Pullman WA 99164 USA 3Texas Agricultural Experiment Station San Angelo TX 76901 USA 4School of Veterinary Medicine University of California Davis CA 95616 USA Received 31 October 2007 accepted 13 May 2008 Abstract- Scrapie eradication efforts cost 18 million dollars annually in the United States and rely heavily upon PRNP genotyping of sheep. Genetic resistance might reduce goat scrapie and limit the risk of goats serving as a scrapie reservoir so PRNP coding sequences were examined from 446 goats of 10 breeds 8 of which had not been previously examined at PRNP. The 10 observed alleles were all related to one of two central haplotypes by a single amino acid substitution. At least five of these alleles M142 R143 S146 H154 and K222 have been associated with increased incubation time or decreased odds of scrapie. To the best of our knowledge neither S146 nor K222 has been found in any goats with scrapie though further evaluation will be required to demonstrate true resistance. S146 was more common present in several breeds at widely varying frequencies while K222 was observed only in two dairy breeds at low frequency. Overall this study provides frequency data on PRNP alleles in US goats shows the pattern of relationships between haplotypes and demonstrates segregation of multiple scrapie-associated alleles in several breeds not examined before at PRNP. scrapie goat polymorphism resistance prion 1. INTRODUCTION Scrapie is a transmissible spongiform encephalopathy TSE that affects sheep and goats. .

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