TAILIEUCHUNG - Báo cáo sinh học: " Detection of genes influencing economic traits in three French dairy cattle breeds"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Detection of genes influencing economic traits in three French dairy cattle breeds | 77 Genet Sei. Evol. 35 2003 77-101 INRA EDP Sciences 2003 DOI gse 2002037 Original article Detection of genes influencing economic traits in three French dairy cattle breeds Didier Boicharda Cecile Grohsb Florence Bourgeois0 Frederique Cerqueirac Rémi Faugerasc Andre Neaud Rachel Ruppa Yves Amiguesc Marie Yvonne Boscherc Hubert Levezielb a Station de génétique quantitative et appliquée Institut national de la recherche agronomique 78352 Jouy-en-Josas Cedex France b Laboratoire de génétique biochimique et de cytogénétique Institut national de la recherche agronomique 78352 Jouy-en-Josas Cedex France c GIE Labogena 78352 Jouy-en-Josas Cedex France d Département de génétique animale Institut national de la recherche agronomique 78352 Jouy-en-Josas Cedex France Received 25 February 2002 accepted 20 September 2002 Abstract - a project of QTL detection was carried out in the French Holstein Normande and Montbéliarde dairy cattle breeds. This granddaughter design included 1 548 artificial insemination bulls distributed in 14 sire families and evaluated after a progeny-test for 24 traits production milk composition persistency type fertility mastitis resistance and milking ease . These bulls were also genotyped for 169 genetic markers mostly microsatellites. The QTL were analysed by within-sire linear regression of daughter yield deviations or deregressed proofs on the probability that the son receives one or the other paternal QTL allele given the marker information. QTL were detected for all traits including those with a low heritability. One hundred and twenty QTL with a chromosome-wise significance lower than 3 were tabulated. This threshold corresponded to a 15 false discovery rate. Amongst them 32 were genomewise significant. Estimates of their contribution to genetic variance ranged from 6 to 40 . Most substitution effects ranged from to genetic standard deviation. For a given QTL only 1 to 5 families out of 14 were informative. The confidence .

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