TAILIEUCHUNG - Báo cáo " Effect of Sweet potato (Ipomoea batatas (L.) Lam) leaf extract on hypoglycaemia, blood insulin secretion, and key carbohydrate metabolic enzymes in expermentally obese and STZ-induced diabetic mice "

Hypolipidemic, hypoglycaemic effects of the ethyl acetate extract fraction from leaves of sweet potato (Ipomoea batatas (L) Lam.) (Convonvulaceae) in obese and streptozotocin (STZ) induced type 2 diabetic mice were demonstrated. When obese-diabetic mice was administrated orally daily by ethyl acetate fraction of 1000mg lyophilized powder/kg for 21 days, | VNU Journal of Science Natural Sciences and Technology 27 2011 118-124 Effect of Sweet potato Ipomoea batatas L. Lam leaf extract on hypoglycaemia blood insulin secretion and key carbohydrate metabolic enzymes in expermentally obese and STZ-induced diabetic mice Do Ngoc Lien1 Do Van Phuc1 Pham Quynh Lien1 Ngo Thi Trang1 Tran Trung Kien2 Tran Thi Phuong Lien3 Kim Dinh Tien3 Hanoi University of Science VNU 334 Nguyen Trai Hanoi Vietnam 2 Hung Vuong University of Phu Tho Hung Vuong Phu Tho Vietnam Hanoi Pedagogical University Xuan Hoa Vinh Phuc Vietnam Received 14 May 2010 Abstract. Hypolipidemic hypoglycaemic effects of the ethyl acetate extract fraction from leaves of sweet potato Ipomoea batatas L Lam. Convonvulaceae in obese and streptozotocin STZ induced type 2 diabetic mice were demonstrated. When obese-diabetic mice was administrated orally daily by ethyl acetate fraction of 1000mg lyophilized powder kg for 21 days we showed that maximum hypoglycaemic and hypolipidemic effects such as TC TG and LDLc were proven in treated mice compared to the control untreated mice . The hypoglycaemic effects of ethyl acetate extract fraction from leaves of sweet potato so that it accelerated hexokinase activity stimulated insulin secretion and inhibited gluconeogenesis enzymatic activity glucose-6-phosphatase . Keywords Ipomoea batatas leaf obese mice type 2 Diabetes mellitus hypolipidemic and hypoglycaemic effect. 1. Introduction Obesity and diabetic mellitus DM were the diseases among the most common metabolic disorder in developed and developing countries. The disease is increasing rapidly in most parts of the world. In 2008 the World Health Organization reported that there are approximately billion overweight and obese Corresponding author. Tel. 84-4-38582179. E-mail liendn@ persons and over 200 million persons suffered from diabetes mellitus DM and this number will increase in future about 330million by 2025 1 . Abnormalities in

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