TAILIEUCHUNG - Báo cáo " Effect of pomelo (citrus grandis (l). osbeck) peel extract on lipid-carbohydrate metabolic enzymes and blood lipid, glucose parameters in experimental obese and diabetic mice "

The aim of this study was to assess the effects of Pomelo (Citrus grandis (L.) Osbeck) peel extracts (CGE) on activity of lipid-carbohydrate metabolic enzymes such as Carnitine pamitoyl-transferase (CPT), lipase, hexokinase, glucose 6-phosphatase and blood lipid glucose parameters in experimental obese and diabetic mice. The results showed that, in the experimental obese mice treated daily, orally with CGE at dose of 1200 mg/body weight for three weeks, | VNU Journal of Science Natural Sciences and Technology 26 2010 224-232 Effect of pomelo citrus grandis l . osbeck peel extract on lipid-carbohydrate metabolic enzymes and blood lipid glucose parameters in experimental obese and diabetic mice Do Ngoc Lien1 . Nguyen Thi Thuy Quynh1 Do Van Phuc1 Vu Cong Phong2 Phung Thanh Huong3 1 Faculty of Biology College of Science VNU 334 Nguyen Trai Hanoi Vietnam 2Pedagogical University of Ha Noi No-2 3Hanoi University of Pharmacy Received 18 January 2010 Abstract. The aim of this study was to assess the effects of Pomelo Citrus grandis L. Osbeck peel extracts CGE on activity of lipid-carbohydrate metabolic enzymes such as Carnitine pamitoyl-transferase CPT lipase hexokinase glucose 6-phosphatase and blood lipid glucose parameters in experimental obese and diabetic mice. The results showed that in the experimental obese mice treated daily orally with CGE at dose of 1200 mg body weight for three weeks activity of hepatic CPT have been raised from for ethanol extract to for ethyl acetate extract compared to the control. Simultaneous increase of blood lipolytic activity was demonstrated in obese mice treated daily by CGE in comparison with the control. In addition body weight reducing and hypolipidemic effect of the CGE in obese mice were proven clearly. Interestingly the anti-diabetic effect of CGE in diabetic STZ induced mice was demonstrated. Fasting blood glucose levels in diabetic mice treated orally with CGE 1200 mg for three weeks were reduced clearly in comparison with the control diabetic mice untreated p . Especially hepatic hexokinase activity in diabetic mice treated with CGE was raised from for ethanol extract to for ethyl acetate extract in comparison with the control untreated diabetic mice . On the contrary activity of hepatic glucose 6-phosphatase in treated diabetic mice was decreased clearly as compared to untreated diabetic mice p . Keywords Citrus grandis L. Obeck blood .

• Báo cáo khoa học
• pomelo
• citrus grandis
• lipid carbohydrate
• metabolic enzymes
• scientific reports
• research projects
• scientific research
• blood lipid
• Agro biological characteristics
• Pomelo lines varieties
• Technique measures
• Promising pomelo lines
• Thai Nguyen Province
• Isotherm models
• Pomelo fruit peel
• Aqueous solution using pomelo fruit peel
• Aqueous solution
• Removal of Ni(II)
• chính sách kinh tế
• dự án nông nghiệp
• kỹ thuật nông lâm
• trồng trọt chăn nuôi
• kinh doanh nông nghiệp
• Vietnam Journal of Science and Technology
• Modeling of essential oil extraction process
• Application for orange
• Application for pomelo
• Application for lemongrass
• The model parameters
• The solid liquid extraction process
• Antioxidant capacity
• Pomelo peel
• Ultrasound assisted extraction
• Total phenolic content
• Ethanol concentrations
• economic policy
• agricultural projects
• agro forestry techniques
• livestock farming
• agribusiness
• Current situation of rural tourism
• Rural tourism in Tan Trieu Islet
• Dong Nai province
• The pomelo gardens
• Developing rural tourism
• Rural tourism attraction
• Plant Biology
• UDP glycosyltransferase
• Expression analysis
• Intracellular homeostasis
• Box Behnken design
• Flavonoids in pomelos’ peels
• Box Behnken response surface design
• Biological activities
• Flavonoids from the pomelo peel
• Advanced materials and devices
• Selective uric acid sensor
• SrWO4 nanocomposite
• Sonochemical method
• Limit of detection
• Real samples