TAILIEUCHUNG - Báo cáo khoa học: Wisely chosen paths – regulation of rRNA synthesis Delivered on 30 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden

All cells, from prokaryotes to vertebrates, synthesize enormous amounts of rRNA to produce 1–2 million ribosomes per cell cycle, which are required to maintain the protein synthesis capacity of the daughter cells. In recent years, considerable progress has been made in the elucidation of the basic principles of transcriptional regulation and the pathways that adapt cellular rRNA synthesis to metabolic activity, a process that is essential for under | THE FEBS EMBO WOMEN IN SCIENCE LECTURE Wisely chosen paths - regulation of rRNA synthesis Delivered on 30 June 2010 at the 35th FEBS Congress in Gothenburg Sweden Ingrid Grummt Division of Molecular Biology of the Cell II German Cancer Research Center DKFZ-ZMBH-Alliance Heidelberg Germany Keywords chromatin epigenetics noncoding RNA rRNA genes signaling transcription Correspondence I. Grummt Molecular Biology of the Cell II DKFZ-ZMBH Alliance German Cancer Research Center Im Neuenheimer Feld 581 D-69120 Heidelberg Germany Fax 49 6221 423404 Tel 49 6221 423412 E-mail Received 19 July 2010 revised 16 September 2010 accepted 22 September 2010 doi All cells from prokaryotes to vertebrates synthesize enormous amounts of rRNA to produce 1-2 million ribosomes per cell cycle which are required to maintain the protein synthesis capacity of the daughter cells. In recent years considerable progress has been made in the elucidation of the basic principles of transcriptional regulation and the pathways that adapt cellular rRNA synthesis to metabolic activity a process that is essential for understanding the link between nucleolar activity cell growth proliferation and apoptosis. I will survey our present knowledge of the highly coordinated networks that regulate transcription by RNA polymerase I coordinating rRNA gene transcription and ribosome production with environmental cues. Moreover I will discuss the epigenetic mechanisms that control the chromatin structure and transcriptional activity of rRNA genes in particular the role of noncoding RNA in DNA methylation and transcriptional silencing. Introduction Growing cells require continuous ribosome synthesis to ensure that subsequent generations are provided with the ribosomes necessary to support protein synthesis. The more rapidly cells proliferate the more rapidly ribosomes must be synthesized. The synthesis of rRNA the first event in ribosome synthesis is a fundamental .

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