TAILIEUCHUNG - Báo cáo khoa học: Scaffolds are ‘active’ regulators of signaling modules

Signaling cascades, in addition to proteins with obvious signaling-relevant activities (. protein kinases or receptors), also employ dedicated ‘inactive’ proteins whose functions appear to be the organization of the former com-ponents into higher order complexes through protein–protein interactions. The core function of signaling adaptors, anchors and scaffolds is the recruitment of proteins into one macromolecular complex. | MINIREVIEW Scaffolds are active regulators of signaling modules Anita Alexa Janos Varga and Attila Reményi Department of Biochemistry Eotvos Lorand University Budapest Hungary Keywords cellular signaling InaD KSR1 MAPK module phosphorylation of scaffold protein kinase PSD95 signaling cascade signaling scaffold Ste5 Correspondence A. Remenyi Department of Biochemistry Eotvos Lorand University Budapest 1117 Pazmany Peter setany 1 C Hungary Fax 36 1 381 2172 Tel 36 1 372 2500 E-mail remenyi@ Signaling cascades in addition to proteins with obvious signaling-relevant activities . protein kinases or receptors also employ dedicated inactive proteins whose functions appear to be the organization of the former components into higher order complexes through protein-protein interactions. The core function of signaling adaptors anchors and scaffolds is the recruitment of proteins into one macromolecular complex. Several recent studies have demonstrated that the recruiter and the recruited molecules mutually influence each other in a scaffolded complex. This yields fundamentally novel properties for the signaling complex as a whole. Because these are not merely additive to the properties of the individual components scaffolded signaling complexes may behave as functionally distinct modules. Received 18 May 2010 revised 18 August 2010 accepted 24 August 2010 doi Introduction Signaling adaptors anchors docking proteins and scaffolds share only one common property they can physically bind proteins with diverse signaling-relevant activities. These diverse activities include protein and lipid phosphorylation dephosphorylation GTP hydrolysis GDP GTP exchange protein cleavage or membrane depolarization. The proteins carrying out these modifications appear to be less elusive currently we know a great deal about their function structure and evolution although there is a lot to be discovered about their recruiter molecules. All recruiter .

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